"We'll see how people respond to it because it's not going to be the same place, it's not going to be Seattle," he added.
"It's not going to be the same Frasier, it's going to be the man in his next iteration. Hopefully that'll be something people like watching. But I think it'll be funny."
During a panel discussion held last year in celebration of Frasier's 25th anniversary, Grammer insisted he would never commit to a reboot unless all of the show's stars - David Hyde Pierce, Jane Leeves, and Peri Gilpin – signed on.
The new show will go ahead however, without John Mahoney, who played the role of Crane patriarch, Martin, before his death in 2018.
"In my own personal approach to what I've discussed with other people," he said at the time, "is that I wouldn't want to do it without these guys."