However, since coming back from rugby union at the start of the year, the 30-year-old has been played at centre, as coach Andrew Webster placed his faith in Nicoll-Klokstad.
But Tuaupiki’s concussion has left Webster with no other choice but to name Tuivasa-Sheck at fullback, seeing Adam Pompey come into the centres for round four.
Last week, Tuivasa-Sheck said he was committed to playing centre, but Tuaupiki’s absence has forced the Warriors to make the shuffle.
Elsewhere, Wayde Egan has been named at hooker, despite missing the last two weeks with an elbow injury.
The 27-year-old was named to face both the Melbourne Storm and Canberra Raiders, but was withdrawn before kickoff both times, which saw Freddy Lussick come into the starting side.
Warriors team to face Newcastle Knights
1. Roger Tuivasa-Sheck
2. Dallin Watene-Zelezniak
3. Rocco Berry
4. Adam Pompey
5. Marcelo Montoya
6. Luke Metcalf
7. Shaun Johnson
8. Addin Fonua-Blake
9. Wayde Egan
10. Mitchell Barnett
11. Jackson Ford
12. Kurt Capewell
13. Tohu Harris (captain)
Interchange
14. Freddy Lussick
15. Marata Niukore
16. Bunty Afoa
17. Dylan Walker
Reserves
18. Tom Ale
20. Jazz Tevaga
21. Chanel Harris-Tavita
22. Te Maire Martin
23. Ali Leiataua