His lawyer indicated outside court that his client would fight the charges.
NSW Police detective acting superintendent Richard Puffett said Wakeham played an “active role” in the drug ring, noting there were several family connections between the three accused.
“We’ve been investigating for eight months and it’s been a laborious, thorough and very tenacious investigation,” he said.
“We believe this is causing a major disruption in this area of illicit drug supply and in relation to these organised criminal group networks that are a scourge.”
NRL chief executive Andrew Abdo confirmed the matter fell under the league’s authority despite Wakeham only holding a contract with a NSW Cup side.
“He has a contract that’s registered with us, so it’ll be under our jurisdiction and once we know a little bit more around the facts, we’ll be able to make a determination of what the action would be,” he said.
The Sea Eagles confirmed Wakeham’s arrest and said the club would fully co-operate with an NRL integrity unit investigation.
Police allege Sam Amine, 47, was the mastermind of the operation, hitting him with 10 charges including seven commercial drug-supply offences as well as an allegation of knowingly directing the activities of a criminal group.
Some $10 million in assets allegedly linked to him were frozen as part of the joint NSW Police and Australian Federal Police operation.
He did not apply for bail when he appeared in Sutherland Local Court.
The third man arrested, Nabil Allouche, 24, made an unsuccessful bail application at Bankstown Local Court.
He is facing 12 charges, which include five commercial drug-trafficking offences.
The MDMA, commonly known as ecstasy, was found in a search of his car, where 56g of cocaine and about $50,000 in cash were also discovered, police said.
Wakeham, a Fijian national representative, played 25 games with Canterbury between 2019 and 2022 before making 15 appearances for Wests Tigers in the 2023 season.
He was set to captain Blacktown in their NSW Cup match against Canterbury on Sunday after playing 10 games for the team in the current season.
As of Thursday afternoon, Wakeham was still listed in Manly’s reserves list for the team’s NRL clash with Brisbane on Friday night.