It comes as iwi across Northland, now backed by the DHB, have put out calls for unvaccinated travellers to stay away over summer, with plans to set up checkpoints.
Te Tai Tokerau has the lowest vaccination rate in the country, with 76 per cent of eligible people fully vaccinated, compared to national rate of 86 per cent. For Māori, just 63 per cent are fully vaccinated.
The trust said under the Covid-19 Protection Framework it would be "practically impossible" to safely go ahead with the usual events of Waitangi commemorations, which attract 30,000 to 40,000 people annually.
Tipene said they had been in discussions with the Government, including Prime Minister Jacinda Ardern and Te Arawhiti Minister Kelvin Davis and health experts, and decided the risk was simply too high.
"The health and safety of visitors, staff and the local community is of paramount importance to the trust so cancelling the event is the only responsible decision under the circumstances," Tipene said.
"I know many will be disappointed but it is the right call for the times we are in and we will now look for creative ways in which to commemorate the promise of Waitangi.
"All going well, Waitangi Week will be back bigger and better than ever in 2023."
Tipene said he was not aware of events at Waitangi being cancelled before, although it could have occurred during the 1918 influenza epidemic.
"Given the importance of the discussions that take place and as part of the character of the country, especially at a time like this, it is hugely disappointing."
While Waitangi, as the place where Te Tiriti o Waitangi was conceived and first signed, has long been the focus of national commemorations, events take place all across the motu each year.
Tipene said they would support events elsewhere.
"In other years former prime ministers have even gone elsewhere. While people like to be in Waitangi for the spirit, the mana and the mauri, Waitangi commemorations take place in many areas and we encourage those to continue where they feel they are safe to."
Waitangi Treaty Grounds will be working with radio, TV and online broadcasters to deliver a virtual Waitangi Day experience on February 6.
Minister of Māori Crown Relations: Te Arawhiti Kelvin Davis said the Government understood and supported the trust's decision.
"While it's unfortunate that there will be no in-person events at the Waitangi Treaty Grounds next year, there will be other parts of the country who will be celebrating our national day in person, and the virtual Waitangi Day experience will still offer people across Aotearoa a sense of Waitangi Day on the Treaty Grounds," said Davis, also MP for Te Tai Tokerau.