In February 1962, Kennedy issued a permanent economic embargo. That October, US planes photographed Soviet missile sites in Cuba, setting off the nuclear stand-off between the superpowers. The crisis ended when the Kremlin withdrew its missiles, after securing a US promise not to invade Cuba.
The US continued its efforts to assassinate Castro. In the early 1960s there were several outlandish CIA plots against the Cuban leader, including one plan to kill him with an exploding cigar.
After Nixon was elected President in 1968, the US officially ended its campaign to overthrow Castro. Nixon's successors, Presidents Gerald Ford and Jimmy Carter, both made attempts to normalise relations with Havana.
In 1980, around 125,000 Cuban refugees fled the island for the US, damaging relations further.
President Bill Clinton made fresh overtures to Havana. In 1996, however, Cuba shot down two planes in international airspace, killing one Cuban and three Americans.
When Raul Castro took control in 2006, it appeared to present an opportunity for rapprochement. Significantly, Raul Castro and Barack Obama were photographed shaking hands last December at the funeral of Nelson Mandela. If it was not the moment that started the thaw, it was a hairdryer in the icebox.
-Independent