A Pakistan International Airlines (PIA) aircraft has crashed in a residential area near the Karachi Airport.
Pakistan's Aviation Ministry said the flight was carrying 99 passengers and 8 crew members.
Mayor of Karachi at scene of crash said none of the 107 passengers, crew survived.
Flight PK8303 took off from Lahore and was due to land at 2.30pm local time in Karachi but went missing from the radar, Pakistan Airlines spokesman Abdullah Khan told CNN.
The plane was flying from Lahore to Jinnah International Airport, Pakistan's busiest airport.
The BBC's Urdu service said: "Dark clouds of smoke can be seen rising from the crash site in the footage seen on TV.
"According to Pakistani media, the plane crashed in an area near Model Colony where there is a human population."
Several houses were damaged in the area where the plane crashed.
Footage showed plumes of smoke rising from the site of the crash.
Ambulances and rescue officials arrived at the scene to help residents.
CAA sources said that its communication with the plane one minute before its landing was cut off. It is estimated that 91 passengers were aboard the flight, 85 in economy class while six were in business class.
The Pakistan Army Quick Reaction Force & Pakistan Rangers Sindh troops arrived at the crash site shortly to assist the civil administration the relief and rescue efforts.