The problem was he accidentally added an R to the street name and the GPS gave him directions to Laugarvegur, which is in Siglufjorour, a fishing town on the north shore of Iceland about 430km out of his way.
When Santillan arrived there he asked a local woman for help and she let him know he was in the wrong place.
"I just stood there, speechless," the woman said on Facebook, according to the Iceland Monitor, which reported the story on Thursday.
According to Visir, an Icelandic news website, Santillan had a feeling that something might be wrong as he drove over icy roads and noticed signs showing Reykjavik was in the other direction.
But he said he was tired after his flight and put his faith in the GPS.
"I did enjoy the scenery on the way," he said.
"I've never seen anything quite like it."
- AAP