Hundreds will step off a cruise ship from Miami into the city next month, the first such voyage since the U.S. embargo that followed Fidel Castro's 1959 revolution.
While the embargo remains in place, ordinary Cubans have warmed to their 'Yanqui' neighbors, especially after Obama's visit to Cuba last month, the first by a sitting U.S. president in 88 years.
Cuba received a record 3.5 million visitors last year, up 17 per cent from 2014. American visitors rose 77 per cent to 161,000, in addition to hundreds of thousands of Cuban-Americans, testing the country's supply of hotel room, rental cars and beer.
The most recent tourism figures, for January, showed a similar pace of growth.
Small restaurants that cater to both tourists and Cubans have blossomed on the Caribbean island since President Raul Castro five years ago formalized changes designed to remove the Communist state from many small-scale economic activities.
"Private bars can go out and find supplies where they can, I can only sell what the government gives me," said the manager of a state-run bar that ran out of beer, while a private locale upstairs had a fridge full of cold bottles.
At its seventh Communist Party congress next week, Cuba's leadership is expected to push ahead with economic reforms outlined in 2011, although the tight-lipped party has given little sign of what will be discussed.
The congress is the country's main forum for defining leadership and economic policy for the next five years.