Congressmen, activists and victims told a congressional hearing in Washington this week that action was needed to stop a repeat of the estimated 10,000 women who were trafficked to Miami, Florida, for the 2010 match.
Ann Wagner, a Republican in Missouri, claimed that online advertisements now allowed fans to "order an under-age girl to their hotel room as easily as if they were ordering a delivery of pizza".
Maria Odom, a senior official at Homeland Security, told the hearing that girls and young women are "lured with false promises of well-paying jobs or are manipulated by people they trust".
Flyers designed to help workers such as public transport drivers and hotel staff spot potential traffickers and their victims have been handed out by authorities.
Miniature soaps bearing an anti-trafficking hotline number have been distributed for use in hotel bathrooms. Receptionists were told to look out for men paying in cash and checking in younger guests without luggage.
Chris Smith, the New Jersey Republican who is chairman of the congressional committee that oversees global human rights, cautioned that like other big sporting events, the Super Bowl "acts as a sex-trafficking magnet". Advocating "zero tolerance" for what he called "modern-day slavery", he said: "All of us must do our part to protect the women and girls."