The 40 per cent rise alone would cause 100,000 smokers to stub out their last cigarette and reduce consumption by one billion cigarettes next year.
Price rises are considered the most effective way of reducing smoking.
In 2009, 21 per cent of adults smoked, the most recent published national survey shows.
But Dr Laugesen estimates from industry figures showing declining tobacco consumption that this figure has dropped to 16.5 per cent, or 584,000 smokers.
He expected his proposal, supported by other tobacco control experts, would produce a noticeable reduction in heart attack hospital admissions from early next year.
"Quitting smoking halves the excess risk of early death from coronary heart disease within one year, and 10 to 15 years without smoking abolishes the excess all-cause mortality compared to never-smokers of the same age," Dr Laugesen said in the journal.
He said the Treasury had underestimated the impact of the Government's chosen option on quitting and smoking fewer cigarettes
He predicted tobacco excise, expected to take $1.3 billion this financial year, would increase by $139 million over four years, not the $528 million calculated by the Treasury.
* Visit www.parliament.nz to make a submission on the tobacco excise amendment bill.
SMOKE SIGNALS
Government proposal for tobacco excise
* Four annual rises of 10 per cent.
* Expected effect on adult smoking prevalence: down 7 per cent by 2021.
Tobacco control researchers want:
* 40 per cent rise, followed by annual 20 per cent increases.
* Expected effect on prevalence: down 36 per cent by 2016.