A man in his 50s and a teenage girl were killed and another person critically injured in a high-speed crash on the outskirts of Outram yesterday.

The vehicles, a sedan and a utility vehicle, collided at the intersection of Huntly and Church Rds, about 5.30pm.

Outram Fire Station is about 2km from the crash scene, and Chief Fire Officer Stuart Casey said Fire and Emergency New Zealand staff were there within minutes.

They found a white sedan crumpled in one paddock, while nearby a ute had flipped on to its roof.

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The driver had got out of the wrecked sedan, while Fenz staff rushed to free two people from the ute.

"One person in the ute was almost out - the other person we had to cut free," Casey said.

"They have had a big, high-speed impact, unfortunately."

Despite the best efforts of St John ambulance staff, only one person survived to be taken to Dunedin Hospital.

"It was a fantastic response from St John today. We had all the resources that we could have asked for," Casey said.

"But they had sustained critical injuries unfortunately ... this was pretty close to home."

Casey said crash scene investigators were working to determine the cause.

"We have been to some calls at the intersection before, but it's certainly not a black spot by any means," he said.

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Police confirmed two people had died at the crash scene, and one person was transferred to Dunedin Hospital.

No other people were believed to have been in the vehicles.

Before yesterday, eight people had died on Otago roads this year: four drivers, two passengers, one motorcycle rider and one pedestrian.