Police have launched a homicide investigation following the death of a woman in Mangere this afternoon.

The woman died at the scene after it appears she was hit by a vehicle.

Counties Manukau CIB Detective Inspector Colin Higson said a number of enquiries are underway.

"Two other people were injured in the incident – a woman has sustained serious injuries and a man has sustained moderate injuries," he said.

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"There is currently a scene examination underway on Mahunga Drive and part of the road is currently closed while this is ongoing.

"We would like to reassure the public that we do not believe there is any ongoing risk to the community."

A post-mortem examination will be carried out tomorrow.

Higson said the police are unlikely to be making further updates this evening.

One patient with serious injuries and one with moderate injuries were being taken to Middlemore Hospital, a St John spokeswoman said.

Earlier, police and emergency services were called to reports of a serious assault in an area of Mahunga Drive about 3.40pm today.

"We can confirm one person has died at the scene.

"A number of staff are in the area trying to establish what has occurred and whether anyone else has been injured."

Mahunga Drive was expected to be closed for several hours, he said.

A local employee told the Herald at the time said he saw four ambulances, at least four police cars with sirens blaring and several St John emergency SUVs heading down Mahunga Drive.

He understood they were now inside the premises of Oji Fibre Solutions at 20 Mahunga Drive.

A witness said there was an extremely aggravated man in the road talking to police. The witness heard police tell the man that if he wanted to help his wife, he needed to listen to them.

Worksafe said it had been notified of the incident and was making initial inquiries.