TVNZ's director of content Cate Slater said Shortland Street was an important part of TVNZ 2's schedule.
"Fans can't get enough of their favourite drama and so we're grateful for their patience and support as we've prioritised the health and safety of the production.
"We're excited to be back on Thursday and Friday nights later this month. We've got some amazing storylines coming up that viewers are going to love."
South Pacific Pictures CEO Kelly Martin said she was proud of how hard the cast and crew had worked to get the show up and running again.
"It's a testament to their dedication and resilience that we are back to some sort of normal and that fans of the show can once again enjoy the show five nights a week."
Production will continue to adapt to fit with government guidelines.