Russo, who directed Avengers: Endgame with his brother Anthony introduced the latest version of Spider-Man in 2016's Captain America: Civil War.
Joe's brother Antony Russo said bringing the character to the film wasn't easy.
"It was an extremely long and hard process. But we were driven to help make it happen," he said.
He added he wasn't surprised the agreement between Sony and Marvel fell apart.
"We know how hard that marriage was to make in the first place, so the fact that the marriage fell apart isn't that surprising to me and Joe."
The next MCU movie is set to be Black Widow, scheduled for release in May 2020.