According to one audience member it appeared that Bono had been afflicted after inhaling atmospheric "stage smoke."
At first the show was paused as the band left the stage hoping to recover. The audience waited to see if the band would resume the concert after taking a break of about 15 minutes.
But management announced that the show would have to be cancelled.
Fans were clearly disappointed but were understanding about the decision.
Some fans even had some social media fun with the performance mishap.
Before leaving the stage the band promised they would do another show in Berlin to make up for tonight's scrapped concert.
The Berlin concert was part of U2's Experience & Innocence 2018 tour.