Transgender Caitlyn Jenner will soon receive the South Park treatment in the show's upcoming season 19 premiere.

South Park returns in the US for its 19th season and it has been revealed the Comedy Central show will take on Jenner and the topic of transgenders.

"The boys express respect for Caitlyn Jenner," a Comedy Central press release teases, according to Entertainment Weekly.

Titled Stunning and Brave, a reference to Kris Jenner's "amazing and very brave" comments about Caitlyn's recent speech at the ESPYS Awards, the premiere episode will force the South Park boys to face their not-so-politically correct history.

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"There is a new principal at the helm of South Park Elementary. He forces the boys to confront the damage they've done through their history of racism and unconscious bias," the episodes description reads.

"It is the most stunning and brave South Park ever."

South Park has a long history of lampooning transgender issues with character Mr Garrison undergoing gender-reassignment surgery in 2005 and again in 2008.

More recently season 18 episode Cissy satirised radical political correctness surrounding gender identity.

- AAP