She claimed: "I didn't do a studio picture for 10 years. I was fired from a $10 million picture deal and did not see the light of day in a studio picture."
The 13 minutes actress - who has son Homer, 19, with ex-husband Coleman Laffoon and Atlas, 12, with former partner James Tupper - hailed Harrison Ford, 79, her "hero" for standing by her when it seemed her proposed role Six Days, Seven Nights was about to be axed as a result of her relationship with Ellen.
Ford called her at home one morning, she remembered: "He said, 'Frankly my dear, I don't give a damn who you're sleeping with. We have a romantic comedy to make. Let's make it the best one that's ever happened.'
"That is why Harrison Ford is my hero. To stand behind me at such a time when the force of what I was standing up for could have been toppled."
But despite claiming her relationship derailed her career, Anne is "proud" she helped to instigate change.
She said: "Those repercussions that happened, are to me what has created a part of the change. I'm a part of it. It is a badge of honour."