In late afternoon trading in New York, the Dow Jones Industrial Average fell 0.41 per cent, the Standard & Poor's 500 Index declined 0.43 per cent and the Nasdaq Composite Index dropped 0.85 per cent.
"The market has pulled back far enough that people are trying to assess if we've priced the worst of what's known. But with the problems in Europe and the fact the news isn't reassuring, prices are still somewhat soft," Bruce McCain, chief investment strategist at Key Private Bank in Cleveland, Ohio, told Reuters.
Data on the US economy including the labour market and manufacturing failed to offset the worry about the effect of slow growth elsewhere.
In the US, initial claims for state unemployment benefits fell 2,000 to a seasonally adjusted 370,000 last week, according to the Labor Department. The four-week moving average fell 5,500 to 370,000.
The US flash manufacturing Purchasing Managers Index slid to 53.9 in May, a three-month low, from 56.0 in April, according to Markit.
"We are growing at moderate pace of two to two-and-a-quarter per cent, but we have some headwinds that are starting to assert themselves, particularly coming from Europe," Paul Edelstein, an economist at IHS Global Insight in Lexington, Massachusetts, told Reuters.
In Europe, the Stoxx 600 Index ended the day with a 1 per cent advance for the session, as recent declines amid the euro zone debt crisis have brought valuations down to levels that appeal to some investors.
"There is already a lot of bad news priced in," Robert Buckland, Citigroup's chief global equity strategist, wrote in a report dated yesterday, according to Bloomberg. "While it looks like it's going to be another difficult summer for global equity markets, our targets are now suggesting 20 per cent upside by end-2012. We would buy into weakness."