"Under the new circumstances, Hong Kong and Macau still have their unique position and advantages that cannot be replaced," he said.
Guangzhou will function as a central city, while Shenzhen will take on a role as a special economic region and an innovative city, he added.
He also revealed that almost 20,000 people from Macau had applied for a new residency permit, which would allow them to access social and public services in mainland China, since it became available on September 1.
A US$15 billion ($22.1b) bridge connecting Hong Kong and Macau opened last year, and bullet trains will also connect Shenzhen and Hong Kong.