European and American health authorities have identified a number of monkeypox cases in recent days, mostly in young men. It's a surprising outbreak of a disease that rarely appears outside Africa.
Health officials around the world are keeping watch for more cases because, for the first time, the disease appears to be spreading among people who didn't travel to Africa. They stress, however, that the risk to the general population is low.
WHAT IS MONKEYPOX?
Monkeypox is a virus that originates in wild animals like rodents and primates and occasionally jumps to people. Most human cases have been in central and west Africa, where the disease is endemic.
The illness was first identified by scientists in 1958 when there were two outbreaks of a "pox-like" disease in research monkeys - thus the name monkeypox. The first known human infection was in 1970, in a 9-year-old boy in a remote part of Congo.
WHAT ARE THE SYMPTOMS AND HOW IS IT TREATED?
Monkeypox belongs to the same virus family as smallpox but causes milder symptoms.
Most patients only experience fever, body aches, chills and fatigue. People with more severe illnesses may develop a rash and lesions on the face and hands that can spread to other parts of the body.
The incubation period is from about five days to three weeks. Most people recover within about two to four weeks without needing to be hospitalised.
Monkeypox can be fatal for up to one in 10 people and is thought to be more severe in children.
People exposed to the virus are often given one of several smallpox vaccines, which have been shown to be effective against monkeypox. Anti-viral drugs are also being developed.
On Thursday, the European Centre for Disease Prevention and Control recommended all suspected cases be isolated and that high-risk contacts be offered the smallpox vaccine.
HOW MANY MONKEYPOX CASES ARE THERE TYPICALLY?
The World Health Organisation estimates there are thousands of monkeypox infections in about a dozen African countries every year. Most are in Congo, which reports about 6,000 cases annually, and Nigeria, with about 3000 cases a year.
Experts say that patchy health monitoring systems mean many infected people are likely missed.
Isolated cases of monkeypox are occasionally spotted outside Africa, including in the US and Britain. The cases are typically associated with travel to Africa or contact with animals from areas where the disease is more common.
In 2003, 47 people in six US states had confirmed or probable cases. They caught the virus from pet prairie dogs housed near imported small mammals from Ghana.
WHAT'S DIFFERENT ABOUT THESE CASES?
It's the first time monkeypox appears to be spreading among people who didn't travel to Africa. Most of the cases involve men who have had sex with men.
In Europe, infections have been reported in Britain, Italy, Portugal, Spain and Sweden.
Britain's Health Security Agency said its cases are not all connected, suggesting that there are multiple chains of transmission happening. The infections in Portugal were picked up at a sexual health clinic, where the men sought help for lesions on their genitals.
On Wednesday, US officials reported a case of monkeypox in a man who had recently travelled to Canada, where authorities are investigating suspected infections in the Montreal area.
IS MONKEYPOX BEING SPREAD THROUGH SEX?
It's possible, but it's unclear at the moment.
Monkeypox has not previously been documented to have spread through sex, but it can be transmitted through close contact with infected people, their body fluids and their clothing or bedsheets.
Michael Skinner, a virologist at Imperial College London, said it's still too early to determine how the men in the UK were infected.
"By nature, sexual activity involves intimate contact, which one would expect to increase the likelihood of transmission, whatever a person's sexual orientation and irrespective of the mode of transmission," Skinner said.
Francois Balloux of University College London said monkeypox said sex qualifies as the kind of close contact needed to transmit the disease.
The UK cases "do not necessarily imply any recent change in the virus' route of transmission", Balloux said.