Gardner said the semi had overturned and "lost its load".
Lowery then responded asking Gardner if he could "tell what he's carrying there? What's all over the road?".
Jim took his time to respond as the camera zoomed in on the boxes, which appeared to have "fake phallus" printed on the sides.
"Whatever it is, it's gonna take a while to clean up," Gardner finally responded.
While the contents of the trailer were never actually confirmed, it didn't stop minds across the world going straight to the gutter.
Hugely-popular American sports blog Barstool Sports shared the clip.
"A tractor trailer full of dildos and lube flipped and spilt all over a highway in Oklahoma," it tweeted, drawing millions of views and thousands of retweets.