If all goes as planned, Oklahoma State's drones will detect the making of a tornado based on humidity, pressure and temperature data collected while travelling through the guts of a storm - critical details that could increase lead time in severe weather forecasts.
The drones would also be equipped to finally answer meteorologists' most pressing questions.
"Why does one storm spawn a tornado and the other doesn't, and why does one tornado turn into an EF1 and another into an EF5?" asked Jamey Jacob of the university's School of Mechanical and Aerospace Engineering, which is developing the drones.
They could be operating in roughly five years, designers estimate. They are safely controlled by operators with a laptop or iPad, are a fraction of the cost of manned research aircraft and are more reliable than sending up weather balloons to divine a storm's intentions.
The latest tornadoes ripped through the areas of El Reno, Union City and Yukon, just west of Oklahoma City and about 30km from Moore. At least 70 people were injured.
Five tornadoes struck with winds of up to 145km/h, accompanied by very large hailstones. The storms flipped cars and trapped people in their vehicles during rush-hour traffic on a main road.
Brandi Vanalphen, 30, who was among the hundreds of drivers trapped, said: "What got me scared was being stuck in traffic with sirens going off. I started seeing power flashes to the north. I started driving on the shoulder. People started driving over the grass."