In November 2007, police walked into a horror crime scene at an apartment in Perugia.
There was a streaky, bloody handprint on the wall, a ripped bra and leg protruding out from underneath a doona. It belonged to Meredith Kercher, a young and beautiful British exchange student who moved to Perugia from England to study.
Knox was her roommate, an all-American 20-year-old college student who was later portrayed as a sex-crazed, vicious psychopath who was responsible for the murder.
Knox was found guilty of the murder in 2009, alongside her Italian boyfriend Raffaele Sollecito. The wrongful conviction changed her life forever.
After six years of trying to prove their innocence, the pair were acquitted and the case closed in 2015.
Here's what she tweeted:
Understandably, reaction was shift.
"Agreed, the mass persecution of blacks, Muslims, Latinx, & LGBTQ pales in comparison to the tribulations of a single white woman," one person responded.
Others said Knox had "balls" for making a joke like she did but said it was "too soon" on both points.
"I'm sure the family of the murdered girl appreciate you finding the funny side," another said.
She still received some support, with people declaring she had "won the internet".
Memes and jokes
Not everyone is using social media to vent — some are simply having fun with the election as they watch for the official results come in today.
One account might have had a little too much fun and triggered Twitter's wrath after impersonating President Donald Trump.
Satire group The Chaser had their Twitter account shut down after changing their name to Donald Trump and telling Twitter users "don't vote for me, I'm a massive idiot".
The punishment has been swift and severe.
The Chaser lost their coveted blue verified tick but their account is back online after a brief suspension.
Elsewhere online, The Lincoln Project, a league of disenfranchised Republicans who can't bring themselves to vote for their party's pick, shared a digitally altered video of the President dancing aboard a sinking ship.
BBC newsdesk and planning editor Neil Henderson often tweets out the front page of the next day's newspapers, and given the time difference, UK papers will go to print before an announcement has been made.
The Daily Star tabloid has made light of that fact by splashing the front page with a headline that works for either septuagenarian candidate.
The tabloid front page features the rarely used double-dot ellipsis, whether this is fixed before the paper hits the press we'll have to wait and see.
Photos of food that resemble President Trump have been popular online over the last four years and have also been circulated on Wednesday morning.
Others are waiting to see what the eventual outcome will be but are preparing for any event.
Many are anxiously awaiting the results of the election and someone at the meditation and mindfulness app Calm clearly anticipated that, and was savvy enough to alert the marketing team of the potential.
