The jet flew for approximately 15 minutes before fracturing in the sky and falling into the Mediterranean Sea, leaving no survivors.
Months afterwards, 21 passengers met a similar fate flying from London to Johannesburg on South African Airways flight 201. The recovered bodies showing similar injuries to the head and lung as those on flight 781.
The common factor? Square windows.
Pressure concentrating in the four corners of every window, contributing to metal fatigue, which caused the planes to explosively break in mid-air.
"Rounded corners are designed to help distribute the pressure exerted on the window evenly, reducing the likelihood of a window cracking under changing air pressure," said Willis Orlando, Product Operations Specialist at Scott's Cheap Flights.
After investigations into the crash, de Havilland made several design changes, including rounded windows that allowed stress to flow evenly.
This change was also crucial as aircrafts needed to fly higher and faster to limit unnecessary fuel use and be more cost-effective.
As a result, planes needed to be more pressurised and thus able to handle stress build-up.
Despite the changes, commercial sales for de Havilland's design supposedly never fully recovered.