Shortly before her latest comeback at last month's French Open, Williams had complained on Twitter about the fact that "anti doping is here … again … second time this week. Proud to participate to keep the sport clean. Even if they do test me at my current ranking of 454 in the world."
But while Williams's frustration is understandable, it should also be pointed out that athletes returning from a long absence are often the subject of repeated drug tests, as they are seen as part of a higher-risk category than athletes in the flow of regular competition.
When contacted by Telegraph Sport on Thursday, Usada's director of communications Brad Horn confirmed that the organisation "has conducted three test sessions on Serena Williams in 2018, with a total of five tests conducted during those sessions".
Horn added: "It is standard practice on many testing missions to obtain both urine and blood samples."
Horn also stressed that "We talk with athletes all the time about clean sport and our programmes. We spoke with Serena recently, as has been reported, about a recent test mission. Serena has been supportive and engaged with our program, and she is in good standing with our programme."
Williams has clearly undergone more Usada testing than most other tennis players, but then she has also won more titles and achieved more renown. Her sister Venus has given 43 samples overall, two more than Serena Williams herself, while Sloane Stephens has given 19 since 2011, Madison Keys 11 since 2014 and CoCo Vandeweghe 11 since 2015.
The International Tennis Federation's figures are less precise, but they show that Serena Williams has been tested a minimum of 56 times since the data set begins in 2010 and Maria Sharapova – who is not subject to Usada's programme as she plays under the Russian flag – has been tested a minimum of 61 times.