Shapovalov will play Brazilian qualifier Rogerio Dutra da Silva in his first round tonight, and a victory there would seal an enticing rematch with Del Potro.
That battle would be one of the most anticipated matches of the tournament, and Shapovalov is confident he can live up to it.
"I've worked hard in the offseason and I feel like my game's there so I'm ready. I'm confident in myself and I'm sure I'm going to play great," Shapovalov said.
The teenager was voted as the ATP's Most Improved Player of 2017 by his peers, a recognition he says was pleasing but also acts as a reminder to manage increased expectations.
"It's a great award - especially as it was voted by my peers - it shows these guys have seen my hard work - it was really motivating for me.
"There's a couple of eyes on me now but I'm just sticking with my team, focusing on ourselves, and making sure I stay on top of things."
Tonight, it will be more than a couple of eyes on Shapovalov, with one of tennis' next set of stars about to take centre stage.