In 2009, Di Luca was given a two-year ban after testing positive during the Giro for CERA, an advanced form of EPO. That ban was subsequently reduced by nine months after he collaborated with Italian anti-doping authorities.
And after winning the 2007 Giro, Di Luca was banned for three months later in the year for frequent visits to Carlo Santuccione, a physician at the center of a four-year doping investigation titled Oil for Drugs.
Di Luca was stripped of his second-place finish and two stage wins in the 2009 Giro, which was won by Denis Menchov, a Russian rider who was never banned for doping but was often linked to banned drug cases.
Seemingly headed for retirement just a few months before this year's Giro, Di Luca signed with Vini Fantini in April a week before the race began. He fared well in several stages of the Italian classic, with four top-10 finishes.
If he is banned, his results from this year's Giro will be stripped.