"If we were ever to go there with people for long duration, the dust gets in everything," said Logsdon, a NASA adviser and former director of the Space Policy Institute at George Washington University.
"All the Apollo crews complained about the lunar dust getting everywhere."
US astronauts walked on the moon in 1969, and the last explorers of the Apollo era visited in 1972.
The journey to the moon will take about a month and the probe will initially orbit at a height of about 250km for 40 days before moving lower.
After 100 days of measuring chemical variations in the lunar atmosphere, analysing gases and lunar dust grains and looking for water molecules in the lunar atmosphere, the spacecraft will plunge into the moon's surface.
- AAP