Two people are being treated in hospital after a two-car crash that has closed off a busy road in Ōrākei, Auckland.

Reports of a crash came in to police about 6.30am.

Emergency services arrived to find two people injured. One had suffered serious injuries while the other was in a moderate condition.

Ngāpipi Rd is now closed between Paritai Dr and Tāmaki Dr, as officers from the Serious Crash Unit carry out a scene examination at the site.

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"This is expected to take some time," police said.

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"Motorists are advised to plan ahead and expect delays on their commute this morning."

The crash happened about the same time there was a multiple vehicle crash on part of Auckland's busy motorway network.

City-bound motorists are being warned to expect delays after a pile-up just after the Princes St on-ramp, on the Southern Motorway.

An alert was issued by the NZ Transport Agency just after 6.30am, saying the crash was blocking the left lane.

"Expect further delays for citybound [Auckland traffic] through this area."

The crash was cleared from all lanes about 6.45am.

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However, commuters were told to expect delays citybound from Te Irirangi Drive to Princes St as emergency services remain at the scene.