One person has died after a serious crash at the Kawatiri Murchison Highway in Tasman.

The crash involved three vehicles on State Highway 6 and was reported at 2:22pm, a police spokesperson said.

Three other people sustained moderate injuries.

St John earlier confirmed one patient with minor injuries has been taken to Murchison hospital and another with moderate injuries has been taken to Nelson Hospital.

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The road is currently closed just north of Murchison near the stock effluent
station and weighbridge, and no detour is available at this stage.

It is expected to reopen soon, a police spokesman said.

Motorists are advised to avoid the area, if possible.