Northern fire communications shift manager Colin Underwood said one of the trio was extricated from the car and firefighters also stayed on to help paramedics.
A helicopter was also sent to the area from Taupō, but it is understood St John took all three people to hospital via ambulance.
A tow truck removed the car and cleared the road just before 4am.
The crash site close to where eight people were killed in one of the country's most horrific crashes - on State Highway 1 near Ohakuri Rd, in Ātiamuri.
A 9-year-old boy was the sole survivor.
Emergency crews were also called to another crash on State Highway 2 near Tūtira, north of Napier, about 4am.
A central fire communications spokesman said no one was trapped and there had been no major injuries.
