The Serious Crash Unit is at the scene of a serious head-on crash at Omori, beside Lake Taupō.
A helicopter was dispatched this afternoon when one person was trapped in a vehicle with serious injuries, and another with moderate injuries was extracted from a vehicle.
St John said it also sent three vehicles to the scene.
A police spokesperson said the crash at the intersection of State Highway 41 and Pukawa Rd was first reported to emergency services at 12.10pm this afternoon.
In a statement, police asked motorists to avoid the area.
Fire crews are helping clear the scene and direct traffic, but the affected roads remain open.