A few minutes later, a truck then collided with the two vehicles involved in the crash.
"One person was trapped in the truck and was described as having serious injuries. Another person had moderate injuries," the spokeswoman said.
"The Southern Motorway was closed at Te Irirangi Drive and diversions put in place while the person was extracted, and the Serious Crash Unit attended."
The spokeswoman said inquiries are ongoing.
Meanwhile, police said they were advised of a single car crash also at the intersection of Harriett Street and Tinakori Road Off-ramp in Wellington last night.
The car appeared to have caught fire following the crash around 10.25pm.
Two people were taken to hospital with moderate injuries, the spokeswoman said.