"There was evidence of previous strokes in three regions of the brain, both left and right sides," said Glengarry.
He died from sepsis caused by infected pressure sores, or ulcers, on his body from immobility. Some were as large as 5cm.
"Pressure injury can start and come on quite quickly and I would agree this has taken longer than, more than, six hours," said Glengarry.
"Given the presence of multiple stage three or four ulcers, I would expect it to take a great deal longer than six hours.
"Mr Epenisa had multiple risk factors due to his previous strokes, diabetes, former obesity and possible malnutrition."
Malia Li has denied causing her husband's death through "gross negligence".
Her lawyer Mark Ryan said an expert witness will provide evidence that Epenisa's pressure sores were very recent, and Li did not fail to take reasonable steps to prevent the sores from developing or worsening.
It's the second week in her trial before Justice Edwin Wylie.