Ono, who is the widow of the late John Lennon, was often blamed for breaking up the Beatles.
Meanwhile, other users suggested Edwards should quit Little Mix in order to support Malik's desire to lead a "normal" life.
One fan wrote: "What just happened?! Did Perrie made him chose her over his career? Unfair, man. She should also quit if that's the case. Just an opinion (sic)."
Sources previously revealed that Malik was willing to do anything to prove his commitment to the Move singer, 21, after he jetted back to the UK for crisis talks with her following cheating rumours earlier this month.
An insider said: "Zayn's found touring with the band a big strain this time around - he's seriously exhausted and wanted to let his hair down in Thailand.
"Now his plan has backfired and he's gutted Perrie has been left humiliated.
"He's told Perrie he'll do anything to please her and wants to stop pushing their wedding date back. He says he wants to get married this year. But Perrie is finding it hard to let go of what she's seen."
- Bang! Showbiz