Musicians and other celebrities have taken to social media to send the rapper their well wishes and ask the world to "pray for DMX".
"Today is 4/3/21 - it's only right that we celebrate the talent and genius of my brother," LL Cool J tweeted, referencing his hit song "4, 3, 2, 1", featuring DMX.
"Prayers for DMX and his family," Missy Elliott wrote on Twitter.
A chorus of other celebrities joined in on the well wishes, as the rapper remains in serious condition since being admitted to hospital on Friday (US time).
The rapper remains in critical condition at the White Plains hospital in New York.
The rapper has previously opened up about his addiction to crack cocaine, which began when he was 14 after he smoked a marijuana cigarette laced with the drug.
DMX shot to stardom in the early 1990s, with his debut album "It's Dark and Hell Is Hot" in 1998, which received both critical acclaim and commercial success, selling 251,000 copies within its first week of release.
He has since topped the charts numerous times, in the US and around the world.
He is believed to be the father of 15 children, including the four he shares with ex-wife Tashera Simmons.
The musician became a father for the 15th time when girlfriend Desiree Lindstrom had his baby in 2016, according to Us Weekly.
