According to differing reports, it is ambiguous whether or not the real-life Gill had actually undergone gender reassignment surgery or just "passed" as male in life.
If Gill was indeed transgender it may be problematic for Johansson to portray a transgender male when she identifies as a cisgender female, with Twitter users taking the lead to torpedo the film with criticism before it has even begun.
Whereas there is a long tradition of cisgender actors playing trans characters to critical acclaim, the paradigm has shifted in recent years with the transgender movement increasing awareness and visibility of gender-authentic casting.
Transamerica, which earned Huffman an Oscar nomination for Best Actress, was made in 2005—years before the transgender rights movement reached its "tipping point" through the work of actor-activists such as Laverne Cox.
Now, some compare cross-gender casting to the antiquated tradition of "blackface".
Others feel that Johansson seems tone deaf or out of touch with today's identity politics and social justice movements, especially by mentioning Jeffrey Tambor as an acting role model after the Transparent actor was fired for inappropriately touching his transgender castmate.
Or is Johansson just another mainstream Hollywood star with a pattern of appropriating minority identities for her own artistic goals?
Ghost in the Shell, which was a box office disappointment, was directed by Rupert Sanders, who will also direct Rub & Tug.
It remains to be seen whether Sanders and his star will authentically address the concerns around gender representation that social media users have raised.
However, there may be a bigger problem ahead for Johansson who does not bear any physical resemblance to Gill, leaving some to wonder how she will make the physical transformation for the role — gender aside.