Eleanor Laws QC, representing Depp, said: "That is what you use to snort cocaine, isn't it?"
"When I did cocaine, yes," replied Henriquez
The barrister said: "I would suggest that this photograph is some sort of set up, isn't it"'
"It is not," replied Henriquez.
Heard's sister also claimed she witnessed the so-called "stairs incident" in March 2015 and described how a drunken Depp nearly pushed her down the stairs at the couple's penthouse apartment in Los Angeles when she intervened in an argument.
Henriquez claimed he struck her on the arm while at the top of a staircase, causing the actress to say "don't hit my sister" and hit him back.
She said Depp then "really went for Amber", adding that she was "standing right there next to them when Johnny grabbed her by the hair with one hand and I saw him punch her really hard in the head".
Depp has brought a libel case against the publishers of the Sun and its executive editor, Dan Wootton, over an article which called him a "wife beater".
Depp vehemently denies abusing Heard, however she maintains she was attacked by him on a number of occasions in drink- and drug-fuelled rages.
This week's evidence centred around the days before Heard filed for divorce.