"Many 4-legged kids. I play pretend. Adopt don't shop – giddy up! Yes, Norman Productions. 'What, like it's hard?'"
Cuoco's bio now reads: "Yes, Norman."
"Despite a deep love and respect for one another, we have realised that our current paths have taken us in opposite directions," the couple said in a joint statement supplied to The New York Post's Page Six.
The couple said there was "no anger or animosity" between them.
"We have made this decision together through an immense amount of respect and consideration for one another and request that you do the same in understanding that we will not be sharing any additional details or commenting further."
A source told US Weekly the couple has a prenuptial agreement in place that will protect the couples' hefty fortunes.
"Her assets are protected," the source told the publication.
She earned a staggering US$1 million per episode for the Big Bang Theory, and Cook is estimated to be worth US$7.9 billion. His father Scott Cook founded the tax software company Intuit.
Cuoco was married to tennis player Ryan Sweeting between 2013 and 2016, and tied the knot with Cook in 2018.