R.I.P.D., a US$130 million science fiction film about police officers fighting villains in the afterlife, is predicted to take in only about $20 million this weekend. To be considered successful, blockbusters aim to take in about half their budget over the first weekend. The film is being released at the same time as Red 2, a tale of retired hit men starring Bruce Willis and Dame Helen Mirren, which is expected to split the audience.
The series of big budget disappointments has come just a month after Steven Spielberg warned that Hollywood was facing a "meltdown" because of its over-reliance on blockbusters.
Speaking at the University of Southern California last month, Spielberg predicted "an implosion where three or four, or maybe even a half dozen, mega-budget movies are going to go crashing into the ground".
Analysts said the failures were partly a result of competing studios trying to release too many big films at the same time.
There are more than 20 with a budget of more than US$100 million being released this summer, six more than last year.
The studios have ploughed resources into so-called "tent pole" films, which are accompanied by costly marketing, and are expected to make large profits. But to do so, they all need to arrive in cinemas over the summer months.
Until late June, Hollywood had been on course for a record summer, following the success of early hits including Iron Man 3, Star Trek Into Darkness and Fast and Furious 6. However, as fatigue set in with audiences, the movie industry entered what has been labelled the "dud zone", in which big releases have fared less impressively than lower budget productions.
A slew of expensive films remain to be released in late July and August. One exasperated studio head told the Hollywood Reporter: "You had too many $100 million-plus movies, not to mention US$200 million-plus movies, jammed on top of each other. There isn't enough play time, and the result has been more movies that wipe out."