He added: "We're all cogs in a huge big bloody machine, yeah? Some of us have the advantage of being able to activate more cogs than other people. That is it."
The father-of-two was speaking in capacity of his latest project Pitch@Palace the Dragons' Den-type initiative he set up to help budding entrepreneurs.
Andrew established Pitch@Palace following his decision to step down as the UK's special trade representative in 2011.
His twice-yearly event, which links British technology firms with investors, has helped raise funds for hundreds of start-ups since 2014 and seen several notable successes.
He has taken the scheme overseas, most recently to China, where he held a 'boot camp' for aspiring businesses in the communist state.
The Pitch@Palace scheme was set up to give entrepreneurs "the opportunity to meet the people who can help make their business dreams become a reality".
The Duke of York was the fourth busiest royal with 112 days of public engagements in 2016, also travels the world representing the Queen at public expense.