Holden said its discussions with the Government were continuing, and it did not respond to speculation. Industry Minister Ian Macfarlane said he has spoken to Holden and they have denied the reports.
Research released last month suggested that Holden's closure would cost the South Australian economy $1.24 billion and 13,200 jobs alone.
Australian unemployment is currently running at 5.7 per cent.
The Federal Chamber of Automotive Industries says the industry directly employs more than 45,000 people across the country.
The Australian Manufacturing Workers Union says Toyota would be likely to follow suit, meaning the end of the Australian automotive industry.
In that proves to be the case, up to 50,000 jobs could be lost across the country, with second and-third tier suppliers also forced to close their operations, the ABC said.
Ford's exit had long been expected after 20 years of declining fortunes for the industry. Early this year, Ford Australia president Bob Graziano blamed the high Australian dollar, rising costs and "one of the most competitive and crowded automotive markets in the world" for the decision to end local production. He said costs in Australia were twice those of Europe and four times those of Asia. Toyota - the only other Australian vehicle manufacturer - is widely expected to close its lines within the next few years.