In late trading in New York, the Dow Jones Industrial Average dropped 0.67 per cent, the Standard & Poor's 500 Index shed 0.83 per cent while the Nasdaq Composite Index declined 0.95 per cent.
Europe's Stoxx 600 Index, however, ended the day with a 0.8 per cent gain.
Unexpected gains in UK and Italian manufacturing were a welcome change. Separate government reports showed that UK factory output advanced 1.2 per cent in May from the previous month, while Italy's industrial production climbed 0.8 per cent in the same period.
Economists surveyed by Bloomberg News had forecast declines of 0.1 per cent and 0.6 per cent respectively.
Also underpinning sentiment was Monday's agreement by euro zone finance ministers on a bailout of as much as 100 billion euros that should help resuscitate Spain's banking industry.
"This puts us in a position to clean up the Spanish financial system that I think is going to go very deep," Spain's Economy Minister Luis de Guindos said, according to Reuters. "We must make maximum use of the next 18 months to do this clean up ... and bring down debt levels in the Spanish economy."
Still, uncertainty about what lies ahead for the EU remains. Germany's constitutional court signalled it may take as long as three months to rule on the legality of the EU permanent bailout fund.
Separately, Italy's Prime Minister Mario Monti has said he won't seek another term in office when the current one expires next year. While Monti has followed through on key reforms as sought by EU partners, his personal popularity has plummeted.