In afternoon trading in New York, the Dow Jones Industrial Average fell 0.55 per cent, the Standard & Poor's 500 Index declined 0.61 per cent, while the Nasdaq Composite Index shed 1.27 per cent.
"We've come to a period of negative economic surprises," Mark Luschini, the chief investment strategist at Janey Montgomery Scott, told Bloomberg News. "Whether it's a pullback or a corrective phase, I think it'll just be a pause because I don't think the fundamental underpinnings are deteriorating more."
In this subdued economic environment, price increases are hardly a concern. That was clearly reflected in the level of demand for the US Treasury's US$18 billion auction of five-year TIPS, or Treasury Inflation Protected Securities.
The bid-to-cover ratio was 2.2, the least since October 2008, and drew a yield of negative 1.311 per cent versus a forecast of negative 1.384 per cent according to Bloomberg.
Shares of Apple extended their slide, last 2.9 per cent weaker at US$391.21, amid concern about slowing demand for its iPhone.
It was not all bad news however. Investors welcomed results by Verizon Communications and PepsiCo, pushing their shares up 3.2 per cent and 2.8 per cent respectively.
In Europe, the Stoxx 600 Index closed at 283.73, unchanged from the previous close and erasing an earlier gain of as much as 0.7 per cent, according to Bloomberg.
Germany's DAX Index fell 0.4 per cent, while national benchmark stock indexes in Paris and London closed little changed from the previous session.