The airline said it wasn't commercially viable.
Read more: End of the road for world's longest non-stop flight
Emirates said it put the 489-seat A380 on the Dubai-Los Angeles in response to strong demand.
The airline had used a smaller Boeing 777 long range plane on the route since 2008.
Emirates operates 63 weekly flights from Dubai to the US serving seven gateways - Los Angeles, San Francisco, Seattle, Dallas, Houston, Washington DC and New York JFK, where two of the three daily flights are operated with A380s.
A daily service from Dubai to Boston will start next March.
The double decker on the Los Angeles route has 14 first class private suites, 76 lie-flat beds in business class and 399 spacious seats in economy class.
See an Emirates supplied video of the first flight here:
The A380's longest non-stop route on the Emirates' network to date has been the Dubai to New York, covering 11,023km during a flight of 13 hours and 26 minutes. The shortest A380 route is between Hong Kong and Bangkok - a distance of 1900km, with a flying time of two hours 20 minutes.