Tourists from around the world count Hosier Lane on their must-see list when they visit Melbourne, but there isn't much to see today.
Vandals hit the popular street art laneway on Saturday night wearing masks and carrying paint guns.
In footage shared on social media, the men casually paint over hundreds of pieces of priceless art.
Victoria Police is investigating.
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Joe Musco, who shared a video of the vandalism on his Instagram, wrote: "Check this out. These dudes with face masks carrying fire extinguisher filled with paint hit up Hosier lane tonite.
"A lot of awesome art work was destroyed. I don't know mate but that's just s**t. Anyhow that's how it goes."
The attack, first reported by 3AW's Ross and John, was carried out by at least 10 people and was being filmed by a drone.
Ross told listeners this morning the vandals had "obliterated all the street art".
On social media, the vandalism was met with outrage. 10 News journalist Candice Wyatt called it "vandalism by faceless cowards".
The New Daily News Editor Andrea Hamblin wrote: "Sad to see some d***heads ruining Hosier Lane. What was the point?"
Melbourne City Council has been approached for comment.