The message comes as the United States and its Syrian Kurdish allies prepare for what they hope will be a final offensive against one of the last and most significant pockets of Isis-controlled territory near the Iraqi border in Syria, where it is thought Baghdadi is most likely to be hiding.
A second Isis-controlled area exists nearby in the remote desert of eastern Syria that is surrounded by Syrian government forces, backed by their Russian and Iranian allies.
Yet, although it now seems likely that the so-called caliphate will soon be entirely vanquished, there are also signs that Isis is succeeding in reinventing itself as a guerrilla insurgency.
An escalation of small-scale attacks in Iraq in recent weeks have raised concerns that the group may survive beyond its eventual territorial defeat. Two recent reports by the United Nations and the US Government suggest there may still be 30,000 Isis fighters or supporters in Iraq and Syria.
Much of Baghdadi's speech was focused on descriptions of the decline of American influence around the world, for which he claimed credit on behalf of Isis, and its war of attrition against the United States.
America "is living the worst period of its contemporary history," he said, attributing this to two decades of US war against Muslims. He cited the resistance of countries such as Russia, Iran and Turkey to the Trump Administration's policy of imposing sanctions against its foes as evidence that America is a waning power, "held in contempt" even by its allies.