Senior police officer Sarafar Nawaz Shaikh later said two of the injured died at the hospital, raising the death toll to 12.
Shaikh said investigators were not ruling out the possibility the explosion was the work of militants. "We will come up with a clear version once the explosives experts complete their job," he said.
Witness Mohammad Sameer said he was in the crowded bank branch moments before the blast but left shortly before the explosion. He said he rushed back to the damaged bank to rescue victims. "Thank God I left the venue otherwise I would also been among the affected ones," he said.
Many sewage channels in the city have been covered, mostly illegally, by constructing concrete structures over them.
Mukhtar Abro, a local administrator, said illegal construction over the sewage area of the explosion was under notice to vacate and the structures were to be demolished.
In the evening, a bomb apparently planted in a motorcycle parked in a bazaar exploded in the southwestern city of Quetta, killing one passer-by and wounding four others, police said. Senior officer Fida Hussain said two of the wounded were transported to hospital in critical condition. No one claimed responsibility for the blast.
Also on Saturday, the military said they killed three militants during two intelligence-based operations in Khyber Pakhtunkhwa province, which borders Afghanistan. The statement gave no further details of the two operations.