Wallabies coach Michael Cheika said he picked the team on form rather than past performances.
"I have been very pleased with some of the individual performances this season and this has really been the basis of many of these selections," Cheika said.
"It's been great to see the energy that Ned and Karmichael have brought this week. We know Test footy is a different beast and I know they have what it takes to step up.
"Tatafu (Polota-Nau)has been challenging Stephen (Moore) for the number two jersey for many years and his form has warranted his selection.
"Stephen is our captain and he'll be up to the challenge of what both Tatafu and Tolu (Llatu) will bring this series."
Wallabies: Israel Folau, Dane Haylett-Petty, Tevita Kuridrani, Karmichael Hunt, Henry Speight, Bernard Foley, Will Genia, Scott Higginbotham, Michael Hooper, Ned Hanigan, Adam Coleman, Sam Carter, Alan Alaalatoa, Tatafu Polota-Nau, Tom Robertson
Reserves: To be named Friday