Generally utilised in the centres or forward pack, Guthrie was part of the silver medal-winning side at the 2016 Olympics, while also claiming gold at the 2018 Commonwealth Games and picking up bronze four years later.
She also captained her country in touch rugby and won silver at the 2011 World Cup, developing the footwork and handling abilities that made her an attractive proposition for the Titans.
The Sydney Morning Herald reported that, although the NRLW contract window was yet to open ahead of the new season, Guthrie had agreed terms with the Gold Coast club in an expanded 10-team competition.
The Titans finished third in the inaugural NRLW campaign but picked up the wooden spoon in the most recent season, winning one of five games.
But the appeals of the move are understandable for Guthrie, with the NRLW the only avenue of payment for Kiwi rugby players outside of New Zealand.
With shorter seasons and contracts currently allowing athletes to easily switch back to rugby, Guthrie may not be the last to take her talents to league.